USP plans new General Chapter on Supercritical Fluid Chromatography (SFC)

The United States Pharmacopeia (USP) intends to develop a new general chapter on Supercritical Fluid Chromatography (SFC). The chapter is expected to describe the principles of the technique, practical aspects of its application, and provide guidance on experimental setup.

A General Chapter Prospectus dated 02 April 2026 states: "USP has a general chapter <621> Chromatography, which is a harmonized chapter between the European Pharmacopoeia, the Japanese Pharmacopoeia, and the Indian Pharmacopoeia. [...] USP intends to develop a new general chapter <xxx(x)> on Supercritical Fluid Chromatography (SFC) which will add another useful chromatographic technique to the USP-NF toolbox of chromatography that can be used for the analysis of pharmaceuticals and other products [...]"

For further information and the proposed preliminary outline, please refer to the General Chapter Prospectus on the USP website.

Feedback on the intended chapter outline can be submitted until 28 May 2026.