Cleaning validation has been a very important topic for the pharmaceutical industry since the 1980s. With the Barr Case and FDA's Guide to Inspection of Cleaning Validation at the beginning of the 90s, the subject gained fresh momentum. Since that time, cleaning validation has always been one of the possible aspects of a GMP inspection. However, freely-available information on this issue is relatively rare or depends in part very much on the supplier.
On the web portal Scribd, one can find a general presentation on the topic of cleaning validation, which also includes calculation models. Further links to other presentation excerpts are also helpful. The presentation can be found here. Another very helpful tool are the cleaning validation memos appearing on a monthly basis on the website cleaningvalidation.com. Unfortunately, only the latest few issues are available to everyone, see here.
On behalf of the European Compliance Academy (ECA)