End of March, scientists from the Food and Drug Administration, Silver Spring, Maryland, Acumen LLC, Burlingame, California, and Centers for Medicare & Medicaid Services, Baltimore, Maryland published their current data on Transfusion-Related Acute Lung Injury (TRALI) occurrence and risk factors among the U.S. elderly.
They claim to have collected data during 2007 through 2011 and show that Transfusion-related acute lung injury (TRALI) is a leading cause of transfusion-related deaths in the U.S. It occurs mostly within six hours of blood transfusion and the l eading hypothesis suggests the cause is substances released from activated neutrophils.
Following some of the findings:
2,556 TRALI diagnoses reported among 11,378,264 higher rate of blood transfusions among the inpatient transfusion stays for elderly Medicare beneficiaries: elderly 22.46/100,000 stays increased
TRALI rates were higher for platelet- and plasma-containing transfusions
TRALI rates increased by year of the study (2007-2011) and number of units
Significantly higher odds of TRALI among specific groups » persons 65 to 79 years vs. older than 79 years, with TRALI risk declining with advancing age » females vs. males » white versus nonwhite » certain medical histories
post-inflammatory pulmonary fibrosis
cancers of blood forming tissues
pulmonary insufficiency following trauma or surgery